Jane Doe, a 48-year-old accountant with a 30-year history of Obsessive-Compulsive Disorder (OCD) mainly related to checking behaviour, presents with a worsening of mental state. She has been on Sertraline 300 mg OD for the last 20 years and been well controlled. What led to the deterioration and how was the patient treated? The case highlights the importance of avoiding a reductionistic approach and using deconstruction of the mental health disorder in formulation and management. The main circuits involved in OCD are the Cortico-thalamic-striatal- cortical loop (CTSC). Overactivation of this ‘worry loop’ is responsible for the development of obsessions. Selective Serotonin Reuptake Inhibitors (SSRI’s) at higher doses are effective in addressing the malfunctioning in this critical loop to treat the OCD. This page is based on a Wikipedia article written by contributors (read/edit). Text is available under the CC BY-SA 4.0 license; additional terms may apply. Images, videos and audio are available under their respective licenses. Valtrex allergic reaction Price comparison viagra and cialis This dopamine reuptake inhibitor property is highest among all. SSRIS. According to Stahlt in his Essential. Psychopharmacology series, sertraline could be. Sep 9, 2010. Sertraline increases extracellular levels not only of serotonin, but also of dopamine in the nucleus accumbens and striatum of rats. Kitaichi Y1. Degenerates dopaminergic neurons 3. Sertraline and venlafaxine are well known for their use in the treatment and management of depression and these drugs. We report a patient with a parkinsonian syndrome induced by sertraline (Zoloft®), an SSRI antidepressant, whose symptoms resolved after the drug was discontinued. This case prompted us to investigate the effect of sertraline on dopamine metabolism in animals. Sertraline (30 mg/kg, IP) or placebo (vehicle) was administered to two groups of six normal, anesthetized rats and using cerebral microdyalisis extracellular striatal levels of dopamine, the dopamine metabolites (HVA and DOPAC), as well as the serotonin metabolite 5-HIIA were monitored. Received: March 07, 2008Accepted: November 06, 2008Published online: March 06, 2009 Issue release date: March 2009 Number of Print Pages: 9 Number of Figures: 2 Number of Tables: 3 ISSN: 0302-282X (Print) e ISSN: 1423-0224 (Online) For additional information: https:// Background: There is a relative scarcity of studies on major depressive disorder that use objective assessment methods to explore the psychomotor effects of antidepressants. Striatal dopaminergic disturbances are known to be involved in the pathogenesis of major depressive disorder that is associated with psychomotor retardation. Because of its additional dopaminergic mechanism, the psychomotor effects of the selective serotonin reuptake inhibitor sertraline merit further exploration. Methods: In 19 patients diagnosed with a current major depressive episode, clinical variables and graphic motor activity were assessed applying digitized figure copying tasks during a 6-week regimen of sertraline. Patients’ baseline and weekly psychomotor performance was compared with the outcomes of 22 healthy, unmedicated controls. Results: Patients’ psychomotor slowing had improved after 6 weeks on sertraline as reflected by reductions in initiation and movement times on the simple line and figure copying tasks and decreased initiation times for the complex figure copying task relative to their baseline outcomes. Conclusions: The current study found evidence pointing to potential beneficial effects of sertraline after a 6-week treatment period in the lower-order cognitive and motor components involved in the graphic motor performance of depressed patients. Sertraline dopamine Does sertraline increase dopamine? - Quora, Sertraline increases extracellular levels not only of serotonin. - NCBI Where can you buy phenergan Nov 25, 2010. We examined effects of sertraline, fluvoxamine, and paroxetine on extracellular serotonin, dopamine, and noradrenaline levels in the medial. Sertraline increases extracellular levels not only of. - Science Direct. Beneficial effect of antidepressants against. - Pathophysiology. Sertraline - The Drug Classroom. Sep 4, 2015. A commonly prescribed antidepressant may alter brain structures in depressed and non-depressed individuals in very different ways, according. Sertraline is a widely used serotonin reuptake inhibitor that has been shown to. In dopamine reuptake, sertraline is more potent compared to a number of. We report a patient with a parkinsonian syndrome induced by sertraline. A case report and an in-vivo study of the effect of sertraline on dopamine metabolism.