It blocks the effects of the naturally occurring chemical histamine in your body. The drug is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. Phenergan also prevents motion sickness, and treats nausea and vomiting or pain after surgery. Phenergan can be taken with or without food or milk. Take Phenergan exactly as prescribed by your doctor. For cure allergy the needed dose is 25 mg before going to bed. Be careful if you drive or do anything that requires you to be awake and alert. You can repeat the dose within two hours if essential. Avoid drinking alcohol, which can increase some of the side effects of Phenergan. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Generic Name: promethazine (oral) (pro METH a zeen)Brand Names: Phenergan, Phenadoz, Promethegan Phenergan is also found in combination with other medications such as phenylephrine (Prometh Hydrochloride), codeine (Prometh VC), or dextromethorphan (Promethazine DM) Medically reviewed by Kaci Durbin, MD. Phenergan (promethazine) belongs to a group of drugs called phenothiazines. It works by changing the actions of chemicals in your brain. It blocks the effects of the naturally occurring chemical histamine in your body. Phenergan is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. Phenergan also prevents motion sickness, and treats nausea and vomiting or pain after surgery. Phenergan is not for use in treating symptoms of asthma, pneumonia, or other lower respiratory tract infections. 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It contains an agent called promethazine, which is a type of drug called a phenothiazine. This works in the body to reduce the effect of an inflammatory chemical called histamine, which is released by the immune system. The dose you use will usually depend on the type of nausea it is being used to treat. The feeling of sickness, or urge to be sick, is referred to in medical terms as nausea, and is often succeeded by actual sickness, or vomiting. There are a number of reasons why someone might experience nausea, and the treatment method for the condition may vary according to the cause. In the body, it is an area of the brain called the ‘vomiting centre’ which sends signals to the stomach and instigates the muscle spasms that cause sickness. The vomiting centre kicks into action when it receives confusing or irritating stimulus from other parts of the body. 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