It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Mefloquine chloroquine What is hydroxy chloroquine Plaquenil is an antimalareial med. It has an anti-inflammatory effect simular to NSAiDs.helps joint pain and reduces muscle inflammation. Fibro is not an inflammatory process. While I was on it, it did nothing to help the everyday achiness of fibro. The researchers said Plaquenil may not be effective in these patients because much of their hand pain may be due to tendon problems rather than arthritis. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. Plaquenil arthritis pain Hydroxychloroquine Side Effects, Dosage, Uses, and More, Rheumatoid Drug No Help To Arthritis Patients What is hydroxychloroquine and sobPlaquenil alcohol side effects Hi, I have been on Plaquenil an Arava for about 2 and a half years now. I was also on Orencia for 2 years. I just started back with Arthrotec. Te Orencia stopped working for me and I just started Simponi last week. I was having increased stiffness and pain in the achilles tendon area and it was real tough walking. PLAQUENIL" Rheumatoid Arthritis Community - Support Group. Hydroxychloroquine Plaquenil. Plaquenil for fatigue and pain DailyStrength. Inhibition of cytokine production and reduction of T-cell activity is the probable mechanism underlying hydroxychloroquine’s efficacy in RA. The relevance of these inflammatory pathways to OA pathology 21, 22, 31, 32, coupled with the evidence that synovitis is closely correlated with pain in the OA joint. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells these are messengers for your immune system, if you will from interacting with your T-Cells a special type of white blood cell which through a convoluted and boring process, causes inflammation when an infection is found, and these basically malfunction with inflammatory disorders.