Its use is becoming increasingly popular for skin disease, arthritis, and other non-life-threatening forms of disease that have not responded to medications such as hydroxychloroquine or low doses of prednisone. It is intended for general informational purposes only and does not address individual circumstances. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. Chloroquine po 300 mg daily Hydroxychloroquine remission early onset rheumatoid arthritis May 28, 2016 I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems. These medications may also prevent lupus from spreading to certain organs, such as the kidney and central nervous system your brain and spinal cord and may help to reduce flares by as much as 50%. Plaquenil and other anti-malarials are the key to controlling lupus long term, and some lupus patients may be on Plaquenil for the rest of their lives. Do you think I should try the Plaquenil first before starting MTX or is it fine to jump to MTX? From what I read so far, seems like methotrexate is a bigger drug with more side effects so plaquenil would be the better choice. Any information would be helpful. Answer. Both drugs are well tolerated and useful in patients with lupus associated. If you think you may have a medical emergency, immediately call your doctor or dial 911. Never ignore professional medical advice in seeking treatment because of something you have read on the Web MD Site. Methotrexate vs plaquenil for lupus Imuran or methotrexate - Lupus - MedHelp, Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus. Plaquenil and sarafem interactionsAllergic reaction from generic to plaquenilPlaquenil et depression Methotrexate MTX vs. Cellcept for Lupus deleted_user 11/04/2011 Hi all, I was recently taken off of Imuran due to high liver values, but the last blood test was better so I have to go back on an immunosuppressant in additon to the 10 mg. of prednisone I'm now on temporarily. Methotrexate MTX vs. Cellcept for Lupus DailyStrength. MTX vs Plaquenil - Arthritis Information. Mycophenolate Cellcept vs Methotrexate lupus. Hydroxychloroquine can reduce inflammation and so reduce pain, swelling and joint stiffness. If you have lupus it may also improve the rash. It’s often taken in combination with other drugs such as methotrexate. Hydroxychloroquine is a long-term treatment and it may be 12 weeks before you notice the benefit. Before starting on. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. May 07, 2019 Rheumatrex methotrexate is a chemotherapy drug used to suppress the immune system. Its use is becoming increasingly popular for skin disease, arthritis, and other non-life-threatening forms of disease that have not responded to medications such as hydroxychloroquine or low doses of prednisone. SOURCES The Lupus Foundation of America.