Chloroquine autophagy inhibitor

Discussion in 'Aralen 150 Mg' started by Kramer, 04-Mar-2020.

  1. Jupepsype Well-Known Member

    Chloroquine autophagy inhibitor


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Jul 11, 2018 Chloroquine CQ, which is frequently used clinically as an antimalarial agent, is a classic inhibitor of autophagy that blocks the binding of autophagosomes to lysosomes by altering the acidic environment of lysosomes, resulting in the accumulation of a large number of degraded proteins in cells. Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation. Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. ovale, and P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine autophagy inhibitor

    Autophagy Inhibitor Chloroquine Enhanced the Cell Death., Chloroquine inhibits autophagic flux by decreasing autophagosome.

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  6. Chloroquine is a lysosomotropic agent that prevents endosomal acidification 1. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes. This accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes and lysosomes.

    • Chloroquine for research Cell-culture tested InvivoGen.
    • Chloroquine - Wikipedia.
    • Autophagy inhibition in cancer Clinical Trials Update Novus Biologicals.

    Results Autophagy was induced in colon cancer models by exposure to both hypoxia and oxaliplatin. Inhibition of autophagy, either with chloroquine or by downregulation of beclin1 or of ATG5, enhanced sensitivity to oxaliplatin under normal and hypoxic conditions in a synergistic manner. Both bevacizumab and oxaliplatin treatments activate autophagy in HT29 murine xenografts. The addition of chloroquine to bevacizumab-based treatment provided greater tumor control in concert with evidence of. Chloroquine CQ is a lysosomotropic agent with an extensive range of biological effects 1. Historically known for its anti-malarial activity, chloroquine is a widely used biological research tool for studying autophagy inhibition. Research studies demonstrate that chloroquine accumulates in acidic lysosomes and increases the lysosomal pH. Pancreatic ductal adenocarcinoma PDA was responsible for ~ 44,000 deaths in the United States in 2018 and is the epitome of a recalcitrant cancer driven by a pharmacologically intractable oncoprotein, KRAS. Downstream of KRAS, the RAF→MEK→ERK signaling pathway plays a central role in pancreatic carcinogenesis.

     
  7. potembo Moderator

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Chloroquine C18H26ClN3 ChemSpider Chloroquine hydrochloride - DrugBank Chloroquine - LiverTox - NCBI Bookshelf
     
  8. AtBt Moderator

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Hydroxychloroquine should not be used for hand osteoarthritis. Anti-Inflammatory Diet 101 How to Reduce Inflammation Naturally Let me tell you what weaning down from Plaquenil is like.
     
  9. N_N_N XenForo Moderator

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  10. beriv Well-Known Member

    Hydroxychloroquine sulfate FDA Label - AIDSinfo Mar 17, 2020 Drug information on Hydroxychloroquine sulfate for health care professionals.

    SAFETY DATA SHEET Page 1 of 5 Hydroxychloroquine sulfate.