Switching from immediate-release to extended-release: Use same total daily dose of metoprolol Switching between oral and IV dosage forms: Equivalent beta-blocking effect is achieved in 2.5:1 (oral-to-IV) ratio Dizziness (10%) Headache (10%) Tiredness (10%) Depression (5%) Diarrhea (5%) Pruritus (5%) Bradycardia (9%) Rash (5%) Dyspnea (1-3%) Cold extremities (1%) Constipation (1%) Dyspepsia (1%) Heart failure (1%) Hypotension (1%) Nausea (1%) Flatulence (1%) Heartburn (1%) Xerostomia (1%) Wheezing (1%) Bronchospasm (1%) Anxiety/nervousness Hallusinations Paresthesia Hepatitis Vomiting Arthralgia Male impotence Reversible alopecia Agranulocytosis Dry eyes Worsening of psoriasis Pyronie’s disease Sweating Photosensitivity Taste disturbance Lopressor and Toprol XL only Ischemic heart disease may be exacerbated after abrupt withdrawal Hypersensitivity to catecholamines has been observed during withdrawal Exacerbation of angina and, in some cases, myocardial infarction (MI) may occur after abrupt discontinuance When long-term beta blocker therapy (particularly with ischemic heart disease) is discontinued, dosage should be gradually reduced over 1-2 weeks with careful monitoring If angina worsens markedly or acute coronary insufficiency develops, beta-blocker administration should be promptly reinitiated, at least temporarily (in addition to other measures appropriate for unstable angina) Patients should be warned against interruption or discontinuance of beta-blocker therapy without physician advice Because coronary artery disease (CAD) is common and may be unrecognized, beta-blocker therapy must be discontinued slowly, even in patients treated only for hypertension Use with caution in cerebrovascular insufficiency, CHF, cardiomegaly, myasthenia gravis, hyperthyroidism or thyrotoxicosis (may mask signs or symptoms), liver disease, renal impairment, peripheral vascular disease, psoriasis (may cause exacerbation of psoriasis) May exacerbate bronchospastic disease; monitor closely Beta blockers can cause myocardial depression and may precipitate heart failure and cardiogenic shock Sudden discontinuance can exacerbate angina and lead to MI and ventricular arrhythmias in patients with CAD Worsening cardiac failure may occur during up-titration of metoprolol succinate; if such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of metoprolol succinate; it may be necessary to lower the dose of metoprolol succinate or temporarily discontinue it Bradycardia, including sinus pause, heart block, and cardiac arrest, has been reported; patients with 1° atrioventricular block, sinus node dysfunction, or conduction disorders may be at increased risk Increased risk of stroke after surgery May potentiate hypoglycemia in patients with diabetes mellitus and may mask signs and symptoms Avoid starting high-dose regimen of extended-release metoprolol in patients undergoing noncardiac surgery; use in patients with cardiovascular risk factors is associated with bradycardia, hypotension, stroke, and death Long-term beta blockers should not be routinely withdrawn before major surgery; however, impaired ability of the heart to respond to reflex adrenergic stimuli may augment risks of general anesthesia and surgical procedures Metoprolol loses beta-receptor selectivity at high doses and in poor metabolizers If drug is administered for tachycardia secondary to pheochromocytoma, it should be given in combination with an alpha blocker (which should be started before metoprolol is started) While taking beta blockers, patients with history of severe anaphylactic reaction to variety of allergens may be more reactive to repeated challenge Extended release tablet should not be withdrawn routinely prior to major surgery Hydrochlorothiazide, can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma, which can lead to permanent vision loss if not treated; discontinue hydrochlorothiazide as rapidly as possible if symptoms occur; prompt medical or surgical treatments may need to be considered if intraocular pressure remains uncontrolled; risk factors for developing acute angle-closure glaucoma may include history of sulfonamide or penicillin allergy Caution in patients with history of psychiatric illness; may cause or exacerbate CNS depression Beta-blockers can precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease There are no adequate and well-controlled studies in pregnant women Limited data on the use of metoprolol in pregnant women Risk to fetus/mother is unknown; because animal reproduction studies are not always predictive of human response, use if clearly needed Bioavailability: 40-50% (immediate-release) ; 65-77% (extended-release) relative to immediate release Onset: 20 min (IV), when infused over 10 min; onset may be immediate, depending on clinical setting; 1-2 hr (PO) Duration: 3-6 hr (PO); duration is dose-related; 24 hr (ER); 5-8 hr (IV) Peak plasma time: 1.5-2 hr (immediate-release); 3.3 hr (extended-release) Therapeutic range: 35-212 ng/m L The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Metoprolol belongs to the calss of medications know as beta-blockers. It has many functions, including lowering pulse and blood pressure. It can also be used in people who have weak heart muscles to stop/slow the progression of the disease and perhaps even This is daily issue in neurology and headache medicine. Read more Am focusing on difficulties with breathing and chest pain, which could involve cardiac or pulmonary issues, and may be associated with an aortic dissection or a pulmonary embolism. there many factors, poor sleeping, poor diet, too much Fioricet, (acetaminophen butalbital and caffeine) etc...... I do not agree with your "headache medications", as these will certainly result in more severe symptoms in near future. Would strongly urge you sit down with your doctor and sort all of this out asap, or seek er help. Read more See 1 more doctor answer If someone has high blood pressure it can be caused by many thing - stress, medications, caffeine, thyroid issues are some of the causes. Headaches can cause pain which can cause BP to rise, or BP can cause headaches. If some is having these symptoms it would be best to go to the doctor to get evaluated. Read more However, migraine patients using triptans should not exceed 10 single doses monthly to prevent rebound headache.
Hi, I'm happy to hear that Metoprolol works for you. I protested instead of taking more, I looked into some natural way: blood pressure lowering food, harder exercise, yoga breathing, meditation. It's awesome to wake up and not have those little devils wake up with you!! It sounds like you are taking the NON extended release form once a day and it's working and that's awesome. Lopressor WARNING: If you have chest pain (angina) or have heart disease (e.g., coronary artery disease, ischemic heart disease, high blood pressure), do not stop using this drug without first consulting your doctor. I started on the beta blocker coreg took it for 6 months then switched to Metoprolol, lost around 15 pounds ,gave up on caffeine...since I have only very occasional headaches, and near not as sever as it was . One point they wanted to give me an extra pill to Metoprolol-Altace because of my bp went up... Over the past two years, there have been many stress factors in my family, including two surgeries for me, chronic pain, and migraine headaches treated with Zonegran as a preventative; open heart surgery, rage, and emotional problems in an adolescent son who also has Cerebral Palsy, and marital problems. I have had counseling, am currently in marital counseling with my husband, and are beginning family counseling. Your condition may become worse when the drug is suddenly stopped. If your doctor decides you should no longer use this drug, you must gradually decrease your dose according to your doctor's instructions. The major side effects I've experienced are TIREDNESS and, because I already have low BP and vasovagal syndrome, it has made me more prone to passing out then I have been for years. The metoprolol knocks you on your butt when you first start taking it. Long term ratings: 3.2/5 This is a reivew of how effective Metoprolol tartrate (metoprolol tartrate) is for Migraine and for what kind of people. The study is created by e Health Me and is updated continuously. How to use this study: bring a copy to your health teams to ensure drug risks and benefits are fully discussed and understood. Metoprolol tartrate has active ingredients of metoprolol tartrate. (latest outcomes from Metoprolol tartrate 59,602 users) Migraine (headache) has been reported by people with multiple sclerosis, migraine, birth control, rheumatoid arthritis, depression (latest reports from 106,380 Migraine patients). NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. DISCLAIMER: All material available on e Health is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider.
Beta Blockers in the Treatment of Migraine Of all the preventative medicines available across the United States, the drugs known as beta blockers are probably the most frequently prescribed. The "beta" refers to receptors on the blood vessels known as beta receptors. Beta blockers prevent the chemical interaction of certain chemicals with this receptor, hence, the term "beta blockers." Of this family of drugs, the most frequently used drug is Inderal, although others, such as Tenormin and Corgard, will also be used occasionally. Beta blockers were developed primarily for control of cardiac symptoms, but it was found coincidentally that these drugs had a remarkable effect on migraine prevention. After this chance observation was made, studies conducted in the late 1960s and early 1970s confirmed the improvement in migraine with treatment. The studies show that sixty to seventy percent of all migraine subjects experienced a decrease of more than fifty percent in the incidence and severity of their headaches when treated with one of these beta blockers. Two beta blockers are currently FDA approved for use in the preventative treatment of migraine: propranolol (Inderal and Inderal LA) and timolol (Blocadren). Also known as: Kapspargo Sprinkle, Lopressor, Metoprolol Succinate ER, Metoprolol Tartrate, Toprol-XLThe following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care."I have just started metoprolol for migraines and it seems to be working. I have had trouble sleeping and am considering taking only in morning. The dosage is so low my blood pressure is relatively unaffected.""The day after I started using metoprolol I began having side effects. First it was nausea and loss of appetite, then wanting to sleep in the daytime (I never do this), no energy at all, couldn't accomplish anything, anxiety, and felt this way for 3 weeks before it dawned on me it might be the change in blood pressure meds. When I looked up side effects of this drug I knew it was not for me. I am back on Atenolol which had been discontinued manufacturing and already feeling better. Wondering how long the effects of metoprolol will be in my system.
Metoprolol is used for a number of conditions, including hypertension, angina, acute myocardial infarction, supraventricular tachycardia, ventricular tachycardia, congestive heart failure, and prevention of migraine headaches. These three agents are atenolol Tenormin, metoprolol Lopressor, and nadalol. of propranolol in the prophylactic treatment of migraine are listed below.