HSV and VZV infections are opportunistic infections (OIs) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as people with HIV—than in people with healthy immune systems. Off-label use, for example, can include using a drug for a different disease or medical condition. Good medical practice and the best interests of a patient sometimes require that a medicine be used off-label. The guidelines include recommendations on the following uses of valacyclovir hydrochloride: On-label uses: The above list may not include all of the HIV-related uses of valacyclovir hydrochloride recommended in the guidelines. Some recommended uses, such as uses in certain rare circumstances, may have been omitted. Take valacyclovir hydrochloride according to your health care provider’s instructions. Your health care provider will tell you how much valacyclovir hydrochloride to take and when to take it. To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more VALACYCLOVIR (val ay SYE kloe veer) is an antiviral medicine. It is used to treat or prevent infections caused by certain kinds of viruses. Do not take your medicine more often than directed. Examples of these infections include herpes and shingles. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Finish the full course prescribed by your doctor or health care professional even if you think your condition is better. They need to know if you have any of these conditions: -acquired immunodeficiency syndrome (AIDS) -any other condition that may weaken the immune system -bone marrow or kidney transplant -kidney disease -an unusual or allergic reaction to valacyclovir, acyclovir, ganciclovir, valganciclovir, other medicines, foods, dyes, or preservatives -pregnant or trying to get pregnant -breast-feeding Take this medicine by mouth with a glass of water. Do not stop taking except on the advice of your doctor or health care professional. Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 2 years for selected conditions, precautions do apply. -cimetidine -probenecid This list may not describe all possible interactions.
Valaciclovir, also spelled valacyclovir, is an antiviral drug used in the management of herpes simplex, herpes zoster (shingles), and herpes B. It is a prodrug, which is converted to aciclovir in a persons body. Common adverse drug reactions (≥1% of patients) associated with valaciclovir therapy are the same as for aciclovir, its active metabolite, and include: nausea, vomiting, diarrhea and headache. Infrequent adverse effects (0.1–1% of patients) include: agitation, vertigo, confusion, dizziness, edema, arthralgia, sore throat, constipation, abdominal pain, rash, weakness and/or renal impairment. Rare adverse effects ( Valaciclovir belongs to a family of molecules first described and patented by Paolo Cornaglia Ferraris in 1982 (patents EP0077460 A2, CA1258149A1, DE3273785D1, EP0077460A3, EP0077460B1, US4567182). Valaciclovir is a prodrug, an esterified version of aciclovir that has greater oral bioavailability (about 55%) than aciclovir (10–20%). It is converted by esterases to the active drug aciclovir, as well as the amino acid valine, via hepatic first-pass metabolism. In the aftermath of disaster, you evacuate your home with your family and your bug-out bag. For one reason another, you overlooked swapping out your three year old medications and now are faced with a dilemma. I am not a medical professional but everything that I have read says, yes, they are not only safe but that the expiration dates on drugs as printed or stamped on those bottles represent more of a CYA for the manufacturers than any thing else. According to the Harvard Medical School Family Health Guide: Most of what is known about drug expiration dates comes from a study conducted by the Food and Drug Administration at the request of the military. With a large and expensive stockpile of drugs, the military faced tossing out and replacing its drugs every few years. What they found from the study is 90% of more than 100 drugs, both prescription and over-the-counter, were perfectly good to use even 15 years after the expiration date. So the expiration date doesn’t really indicate a point at which the medication is no longer effective or has become unsafe to use. Medical authorities state expired drugs are safe to take, even those that expired years ago.
Mar 3, 2014. One of the most frustrating aspects of our health system is the expiration dates on drugs. Here are 11 facts about expiration dates on. Valaciclovir, also spelled valacyclovir, is an antiviral drug used in the management of herpes. It is marketed by GlaxoSmithKline under the trade names Valtrex and Zelitrex. Valaciclovir has been available as a generic. To date, resistance to valaciclovir has not been clinically significant. Mechanisms of resistance in HSV.