One of the pills the dr wants me to take is Prednisone 20mg. BUT she has me prescribed FIVE TABLETS (total 100mg) for five days and then I am off it completely. Then when I have chemo again in 3 wks I will be prescribed do that again. Does that seem abnormally high to you or have some of you taken high doses and is it odd to just drop off afterwared? Each time I had chemo I was given the Pred,20mg for 5 days. I'm asking the dr tomorrow but would like some feedback. It is a high dose if you are not used to taking it. It will keep you awake and in some people it has other reactions. It only kept me up all night long dancing on the ceiling. John Hi, 100mg a day for 5 days is pretty standard. By the way you will find that to be a lonely time because you are by yourself. I was able to talk my doctor into lowering my dose to 60mg a day, however, I did not do R-CHOP, but instead CVP-R. Prednisone is used for many different autoimmune diseases and inflammatory conditions, including: asthma, COPD, CIDP, rheumatic disorders, allergic disorders, ulcerative colitis and Crohn's disease, adrenocortical insufficiency, hypercalcemia due to cancer, thyroiditis, laryngitis, severe tuberculosis, urticaria (hives), lipid pneumonitis, pericarditis, multiple sclerosis, nephrotic syndrome, sarcoidosis, to relieve the effects of shingles, lupus, myasthenia gravis, poison oak exposure, Ménière's disease, autoimmune hepatitis, giant-cell arteritis, the Herxheimer reaction that is common during the treatment of syphilis, Duchenne muscular dystrophy, uveitis, and as part of a drug regimen to prevent rejection after organ transplant. It is important in the treatment of acute lymphoblastic leukemia, non-Hodgkin lymphomas, Hodgkin's lymphoma, multiple myeloma, and other hormone-sensitive tumors, in combination with other anticancer drugs. Prednisone can be used in the treatment of decompensated heart failure to increase renal responsiveness to diuretics, especially in heart failure patients with refractory diuretic resistance with large dose of loop diuretics. In terms of the mechanism of action for this purpose: prednisone, a glucocorticoid, can improve renal responsiveness to atrial natriuretic peptide by increasing the density of natriuretic peptide receptor type A in the renal inner medullary collecting duct, inducing a potent diuresis. Short-term side effects, as with all glucocorticoids, include high blood glucose levels (especially in patients with diabetes mellitus or on other medications that increase blood glucose, such as tacrolimus) and mineralocorticoid effects such as fluid retention. The mineralocorticoid effects of prednisone are minor, which is why it is not used in the management of adrenal insufficiency, unless a more potent mineralocorticoid is administered concomitantly. It can also cause depression or depressive symptoms and anxiety in some individuals.
Prednisone is used to treat conditions such as arthritis, blood disorders, breathing problems, severe allergies, skin diseases, cancer, eye problems, and immune system disorders. Prednisone belongs to a class of drugs known as corticosteroids. It decreases your immune system's response to various diseases to reduce symptoms such as swelling and allergic-type reactions. Take this medication by mouth, with food or milk to prevent stomach upset, as directed by your doctor. Take the tablet form of this medication with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. The comments you read were probably in regards to taking prednisone while actively infected with HCV. Prednisone is an immunosuppressant so it reduces the intensity of your immune system while you're taking it. This can make you more likely to succumb to both bacterial and viral infections. Or, if you are already infected with a virus like HCV, it will increase your viral load, viral activity and probably the rate of liver fibrosis (although I don't have a study offhand to confirm that part). I checked all the drugs your mother is currently taking (fluorouracil and irinotecan in FOLFIRI regimen, morphine, prozac, prednisone) and all of these, particularly the chemotherapy drugs, do not appear to have any significant interactions with lithium. The exception is prozac, which has enhanced effects when combined with lithium. I suggest that you have your mother's lithium levels checked as soon as possible (this should be done periodically, anyway).
The CHOP cyclophosphamide, hydroxyldaunomycin doxorubicin, oncovin vincristine, and prednisone chemotherapy regimen has become the gold standard. You should not use this medication if you are allergic to prednisone, or if you have a fungal infection that requires oral antifungal treatment. Steroid medication can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had.