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Description Metronidazole tablets are an antibiotic used to kill or prevent the growth of bacteria or other microorganisms and is approved for the treatment of inflammatory lesions and rosacea, vaginosis and vaginitis. It is used off-label to treat hepatic encephalopathy by reducing the excessive amount of ammonia-producing bacteria in the body. Original uses (on-label) Treatment of susceptible anaerobic bacterial and protozoal infections, topical treatment of inflammatory lesions and rosacea, bacterial vaginosis and vaginitis due to susceptible organisms (vaginal preparations). Potential side effects Uncoordinated gait, confusion, dizziness, hives, disulfiram-like reaction (flushing, nausea, vomiting), nausea, vomiting, constipation, diarrhea, metallic taste, darkened urine, blood disorders (low white blood cell count), weakness, flu-like syndrome. Vaginal preparation: stomach cramps, abdominal cramps, vaginitis, vaginal itching or swelling. Topical preparation: skin redness, itching, rash, dryness, worsening of rosacea. Drug interactions Cimetidine, benzodiazepines, calcium channel blockers, cyclosporine, remeron, nateglinide, nefazodone, sildenafil, tacrolimus, venlafaxine, lithium, phenytoin, phenobarbital, warfarin. Unnecessary exposure to metronidazole in breast-feeding infants should be avoided. Special information This drug has a black box warning regarding a carcinogenic effect noted in animals. Vaginal formulation: Do not engage in sexual intercourse during therapy. Flagyl Flagyl is one of the drugs, suitable for the rapid treatment of intractable bacterial and fungal infections. Flagyl solves the main task of treating infectious diseases – it stops the infectious process at the initial phase of its development and does not allow its further progression. Prescribing Information Flagyl is a highly active antimicrobial and antiprotozoal drug that has a broad spectrum of activity against infectious and parasitic infections. The spectrum of therapeutic indications for the use of Flagyl is unusually wide: The action mechanism of Flagyl lies in the inhibition of the nucleic acids synthesis that are necessary for the life of microorganisms. The violation of bacterial DNA eventually leads to their death. In antimicrobial and antiparasitic therapy, tablets, capsules, oral suspension, rectal and vaginal (pessary) suppositories, as well as Flagyl injection, can be used. Dosage The dosage of Flagyl depends on which dosage form was chosen for antibiotic therapy.

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