Sertraline is used for a number of conditions, including major depressive disorder (MDD), obsessive–compulsive disorder (OCD), body dysmorphic disorder (BDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder (SAD). The comparative efficacy of sertraline and TCAs for melancholic depression has not been studied. A 1998 review suggested that, due to its pharmacology, sertraline may be more efficacious than other SSRIs and equal to TCAs for the treatment of melancholic depression. A meta-analysis of 12 new-generation antidepressants showed that sertraline and escitalopram are the best in terms of efficacy and acceptability in the acute-phase treatment of adults with unipolar MDD. Sertraline used for the treatment of depression in elderly (older than 60) patients was superior to placebo and comparable to another SSRI fluoxetine, and TCAs amitriptyline, nortriptyline (Pamelor) and imipramine. Sertraline had much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurred more frequently with sertraline. In addition, sertraline appeared to be more effective than fluoxetine or nortriptyline in the older-than-70 subgroup. placebo in elderly patients showed a statistically significant (that is, unlikely to occur by chance), but clinically very modest improvement in depression and no improvement in quality of life. A meta-analysis on SSRIs and SNRIs that look at partial response (defined as at least a 50% reduction in depression score from baseline) found that sertraline, paroxetine and duloxetine were better than placebo. An amazing thing happened when I began doing research for this story. I put a callout on my personal Facebook page and was immediately flooded with responses from close friends and relatives. These are women I've spent a lot of time with—explored the tiny dark corners of our insecurities, discussed politics, shared secrets, and offered catharsis in the wake of failed relationships or family troubles. And yet, I had no idea the majority of them were dealing with clinical depression. It's that exact point—how we still feel like it's relatively taboo to expose our experience with mental health issues even when we're in open, honest, and liberal relationships—that makes sharing all the more crucial. Still, it's just one of the endless reasons to continue to solidify this platform as more of a helpful, thorough resource for mental health education and awareness. According to the Anxiety and Depression Association of America, over three million adults are directly affected by persistent depression.
I can’t think of much that's less arousing in the middle of sex than starting a conversation about the side effects of my antidepressants. But this is something I’ve had to do often, usually after my partner asks, “Did you come? (I more than likely haven’t.) Then I know it’s time to have the talk about how my brain makes me sad for no reason, why all the sex things I used to like feel like absolutely nothing, and why, if you're having sex with me, you should probably get comfortable and adjust your neck position, because we’re going to be here for a while. I’ve struggled with depression and severe anxiety on and off since I was around 13, an age when the more subtle signs of depression like moodiness, irritability, and social withdrawal can easily go undiagnosed since teenagers are often known for being moody, irritable, and sometimes withdrawn. The adults in my life often wrote my symptoms off as “hormonal,” “typical teen stuff,” and, later, when I was able to see a therapist on my own, a run-of-the-mill teenage crisis that I’d “grow out of.” I tried everything happy people told me would supposedly help: herbal tea, bubble baths, getting a haircut, pretending I was fine, a gluten-free diet, a juice cleanse, yoga, “thinking positive." While some of these things might help turn around a bad day, they won’t do anything when it’s been a bad six to eight months. I thought maybe I was a sad, boring person who couldn’t be motivated to get it together, no matter how hard I tried. After a while, I didn’t have the energy to try to change. As I entered my 20s, my frequent panic attacks and near-constant negative thoughts about myself were so overwhelming that I could barely get out of bed. All I could hear was the voice in my head telling me, “You’re not smart enough,” “No one loves you,” “You’re a disappointment,” and “You’re ugly,” over and over again until I started to believe these things were true. Even if you aren’t aware of it, the chances are good that someone you know is taking some sort of psychiatric medicine. According to the most recent research, an estimated one in six adults in the U. have a prescription for antidepressants, anti-anxiety pills, or some other drug to help them manage their mental health. And with those drugs, for many of those people, come the side effects — some of which can feel dire enough to become a problem in and of themselves, requiring a second treatment to offset the first. Many commonly prescribed antidepressants, in particular, can come with a host of side effects that can paradoxically contribute to depression. “Antidepressants saved my life and killed my orgasms,” writer Sofia Barrett-Ibarria recently declared in magazine; problems with sex are common, as are struggles with weight. Auxiliary medications are often prescribed to mitigate the severe side effects of primary medications, but can come with their own, like tinnitus and digestion issues. The end result is that seeking treatment for mental illness is often a delicate tightrope walk toward health, one that forces patients to consider any number of trade-offs and carefully evaluate exactly what it means to live a good, happy life.
Sertraline, sold under the trade name Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor SSRI class. It is used to treat major. Zoloft official prescribing information for healthcare professionals. Includes indications, dosage, adverse reactions, pharmacology and more.