While once a first-line treatment for hypertension, the role for beta blockers was downgraded in June 2006 in the United Kingdom to fourth-line, as they do not perform as well as other drugs, particularly in the elderly, and evidence is increasing that the most frequently used beta blockers at usual doses carry an unacceptable risk of provoking type 2 diabetes. Propranolol is not recommended for the treatment of hypertension by the Eighth Joint National Committee (JNC 8) because a higher rate of the primary composite outcome of cardiovascular death, myocardial infarction, or stroke compared to an angiotensin receptor blocker was noted in one study. Propranolol works to inhibit the actions of norepinephrine, a neurotransmitter that enhances memory consolidation. In one small study individuals given propranolol immediately after trauma experienced fewer stress-related symptoms and lower rates of PTSD than respective control groups who did not receive the drug. Due to the fact that memories and their emotional content are reconsolidated in the hours after they are recalled/re-experienced, propranolol can also diminish the emotional impact of already formed memories; for this reason, it is also being studied in the treatment of specific phobias, such as arachnophobia, dental fear, and social phobia. Ethical and legal questions have been raised surrounding the use of propranolol-based medications for use as a "memory damper", including: altering memory-recalled evidence during an investigation, modifying behavioral response to past (albeit traumatic) experiences, the regulation of these drugs, and others. However, Hall and Carter have argued that many such objections are "based on wildly exaggerated and unrealistic scenarios that ignore the limited action of propranolol in affecting memory, underplay the debilitating impact that PTSD has on those who suffer from it, and fail to acknowledge the extent to which drugs like alcohol are already used for this purpose." Propranolol may be used to treat severe infantile hemangiomas (IHs). Objective is to maintain a resting heart rate of 50-60 bpm since I have grade three varices caused from portal hypertension a symptom of stage C decompensated cirrhosis. Since beginning this new medications (taken before bed) I wake up many morning with my heart pounding really hard then after about an half hour it returns to normal. Could this be a side effect of the medication or something else? I was given propranolol 10mg, twice a day to control my rapid heart rate and SVT runs-- it worked wonderfully at regulating my heart rate! my heart beating does not bother me when it's in sinus rhythm (even when it's 190) but on this beta blocker my heart beat was truly a background function! Hello, I have had chronic migraines for 3 years and any loud noise, sudden change (even emotional) would get my heart racing along with a bad migraine. it was crazy, all these years, I guess I did notice my heart beat ... I was on propranolol 60 mg a day, which worked well. Get a hobby to take your mind off your troubles, or adopt a cat from a shelter and spoil it rotten. I switched to metropolol which isnt working as well but I still have not fixed the dose. I had catheter ablation on june 19 2013 it has been almost 6 months and now my heart rate is 155 my ep told me I need to go back on 80 mg propranolol which is why I had the ablation so I wouldn't have to take beta blockers no more...makes no sense.... More importantly, I have finally got to the root cause of my migraines. Doctor prescribed Inderal for panic and anxiety after a different doctor had gotten me addicted to Xanax, which is a different story.
Propranolol hydrochloride is a stable, white, crystalline solid which is readily soluble in water and ethanol. Its molecular weight is 295.80. Inderal LA is formulated to provide a sustained release of propranolol hydrochloride. Inderal LA is available as 60 mg, 80 mg, 120 mg, and 160 mg capsules. I take propranolol 80 mg er once daily. Objective is to maintain a resting heart rate of 50-60 bpm since I have grade three varices caused from portal hypertension a.