Researchers compared the use of doxycycline to placebo, after enrolling more than 400 obese women with knee arthritis as study participants. The study participants were randomized into two groups, receiving either 100 mg of doxycycline twice daily or a placebo for up to 2.5 years. Researchers analyzed the impact of doxycycline on the joint space of the affected knee. Following 16 months of treatment, results indicated that the average loss of joint space in the affected knee was 40% less among participants taking doxycycline than those who took a placebo. At the end of the two and a half year period, the loss of joint space was 33% less in the group who took doxycyline than in the placebo group. Doxycycline was also associated with less patient-reported increases in knee pain. Researchers acknowledged, though, that the average level of pain was low in both groups. Applies to doxycycline: oral capsule, oral capsule extended release, oral powder for suspension, oral syrup, oral tablet, oral tablet delayed release Along with its needed effects, doxycycline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Some side effects of doxycycline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to doxycycline: injectable powder for injection, oral capsule, oral delayed release capsule, oral delayed release tablet, oral kit, oral powder for reconstitution, oral syrup, oral tablet, oral and topical kit Very common (10% or more): Headache (up to 26%) Common (1% to 10%): Sinus headache Rare (0.01% to 0.1%): Bulging fontanels (in infants), benign intracranial hypertension (pseudotumor cerebri [symptoms include blurred vision, scotomata, diplopia]), tinnitus Frequency not reported: Hypoesthesia, increased intracranial pressure, paresthesia, somnolence, stupor, taste loss, drowsiness, amnesia, paresthesias of body areas exposed to sunlight, phrenic nerve paralysis after sclerotherapy Postmarketing reports: Pseudotumor cerebri, headache, dizziness Benign intracranial hypertension resulting in permanent loss of vision has been reported. A 70-year-old female patient with no significant medical history suddenly developed a severe headache followed by vomiting about 15 minutes after the initial dose of this drug.
Oct 18, 2011. Rheumatoid arthritis patients with minocycline and doxycycline. and patient-reported pain 16, comparable with hydroxychloroquine 27. OBJECTIVE To confirm preclinical data suggesting that doxycycline can slow the. Doxycycline did not reduce the mean severity of joint pain, although pain.