Prednisolone wikipedia

Posted: George White Bayov Date of post: 15-Feb-2019
<b>Prednisolone</b> - Side Effects, Uses, Dosage, Overdose, Pregnancy.

Prednisolone - Side Effects, Uses, Dosage, Overdose, Pregnancy.

Prednisolon (1,2-Dehydrocortisol; früher auch Metacortandralon oder Deltahydrocortison genannt) ist ein synthetisches Glucocorticoid. Prednisolon ist ein aktiver Metabolit des Prednison. Seit 1957 wird Prednisolon als „Solu-Decortin H“ von Merck in Deutschland vermarktet. Beide Kristallformen stehen somit enantiotrop zueinander, wobei das tiefer schmelzende Polymorph die bei Raumtemperatur thermodynamisch stabilere Form darstellt. Die Hydratform besitzt eine 1,5-Stöchiometrie und kann aus Methanol-Wasser-Gemischen kristallisiert werden. Prednisolon besitzt eine ausgeprägte immunsuppressive und darüber entzündungshemmende, antiallergische Wirkung. Es ist Wirkstoff der Wahl für systemische antiinflammatorische und immunsuppressive Effekte. When it comes to ulcerative colitis, there are different options for treatment. The treatment your doctor prescribes for you often depends on the severity of your symptoms. Two drugs you may hear about are prednisone and prednisolone. (A third drug, methylprednisolone, is stronger than both and should not be confused with prednisolone.) Here’s the rundown on what these drugs are and how they can help treat ulcerative colitis, including how they’re alike and how they’re different. Prednisone and prednisolone both belong to a class of drugs called glucocorticoids. Glucocorticoids reduce inflammation throughout your body. They do this by interfering with the way certain chemicals in your body cause inflammation. These drugs can work in different parts of your body, including your colon. Your colon is the last section of your large intestine, just before your rectum.

<i>Wikipedia</i>

Wikipedia

Prednisone is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant drug. It is used to treat certain inflammatory diseases (such as moderate allergic reactions), some autoimmune diseases, and (at higher doses) some types of cancer, but it has significant side effects. Prednisone is used for many different autoimmune diseases and inflammatory conditions, including: asthma, COPD, CIDP, rheumatic disorders, allergic disorders, ulcerative colitism Crohn's disease, adrenocortical insufficiency, hypercalcemia due to cancer, thyroiditis, laryngitis, severe tuberculosis, hives, lipid pneumonitis, pericarditis, multiple sclerosis, nephrotic syndrome, sarcoidosis, to relieve the effects of shingles, lupus, myasthenia gravis, poison oak exposure, Ménière's disease, autoimmune hepatitis, the Herxheimer reaction that is common during the treatment of syphilis, Duchenne muscular dystrophy, uveitis, and as part of a drug regimen to prevent rejection after transplant. Prednisone has also been used in the treatment of migraine headaches and cluster headaches and for severe aphthous ulcer. It is important in the treatment of acute lymphoblastic leukemia, non-Hodgkin lymphomas, Hodgkin's lymphoma, multiple myeloma, and other hormone-sensitive tumors, in combination with other anticancer drugs. Prednisone can be used in the treatment of decompensated heart failure to increase renal responsiveness to diuretics, especially in heart failure patients with refractory diuretic resistance with large dose of loop diuretics. In terms of the mechanism of action for this purpose: prednisone can improve renal responsiveness to atrial natriuretic peptide by increasing the density of natriuretic peptide receptor type A in the renal inner medullary collecting duct, inducing a potent diuresis. Patients on prednisone therapy require frequent medical attention, generally to perform blood tests and to check blood pressure. Patients usually recognize improvement on prednisone without tests, such as reduction in swelling or pain. For conciseness and simplicity, Hem currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Up To Date (courtesy of Lexicomp), or the prescribing information.

Prednisone - <b>Wikipedia</b>
Prednisone - Wikipedia

Prednisone is a prodrug; it is metabolised in the liver by 11-β-HSD to prednisolone, the active drug. Prednisone has no substantial biological effects until converted via hepatic metabolism to prednisolone. Pharmacokinetics. Prednisone is absorbed in the gastrointestinal tract and has a half life of 2-3 hours. Be sure your doctor and lab workers know you take prednisolone oral solution. If you have been taking prednisolone oral solution for many weeks, talk with your doctor before stopping. You may want to slowly stop prednisolone oral solution. You may have more chance of getting an infection. Wash hands often.

Prednisolone wikipedia
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