I know this is probably a silly question coming from a big old lady such as myself but I've been having alot of problems taking these darn pills because of the yucky taste. I'm taking the generic pills and they taste absolutely awful. I always get a little of the bitter after-taste at the back of my tongue, no matter how quickly I take it. And now it's gotten to the point where my gag reflex gets activated just thinking of taking it. As a result I haven't taken them for the past 2 weeks! The side-effects I can handle but the taste has really gotten to me. Anyway the moral of my story is does anyone know if crushing the met and taking it with yogurt or something will diminish it's effectiveness? Even though the matrix is not rigit, it may occasionaly remains intact and excreted in the feces.(Similar to carbamazepin, nifedipine ext rel and others, actually, we need to consult patients about seeing empty matrix in the stool - don't worry if you see ... I have come across with a real case where the patient found Metformin 1000mg XR in the stools with out getting dissolved completely. Also find out if he suffering from any GI disease, cos the tablet needs gastric secretions for the initial phase of dissolution and normal GI peristalsis for the tablet to be broken down later and excreted in feces as a soft mass. If drug brand names have XR, CR, SR, DR like suffix (special ends with "R"), then that drug cannot be crushed... This universal rule does not apply for these categories of drug (buccal drugs). About undissolved pieces of tablets in the stool: since it is extended release tabs, they made a polymer matrix with the drug incorporated into it. Then drug will slowly released from the matrix (based on p H dif). He should be advised to drink water with the med , to aid in dissolution. I believe that extended release formulations can't be crushed, unless manufacturer specifies it. In the case above, we need to find out how he is administering his medication and what is his other disease states.. I don't remember one other drug but on naplex digest they have asked one question on that drug. The whole point of the release technology is lost ,except in special cases like metoprolol succinate where it can be broken along the split line to take half the dose . etc.) If it is dissolution; usually related with moisture not p H. Extended release have to have different release phase (e.g. Metformin have immediate release component and then matrix based extended release component.
I believe that extended release formulations can't be crushed, unless manufacturer specifies it. About undissolved pieces of tablets in the stool since it is extended release tabs, they made a polymer matrix with the drug incorporated into it. Diabetes can be hard on a marriage. But here are six ways that couples can cope with it