This is not a list of all drugs or health problems that interact with azithromycin single-dose packet. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take azithromycin single-dose packet with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. For all patients taking azithromycin single-dose packet: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. However, many people have no side effects or only have minor side effects. A single dose of an oral antibiotic provides treatment for early and latent syphilis that is equivalent to the currently recommended penicillin injection, according to a study reported in the September 22 edition of the New England Journal of Medicine. The investigators found that a single oral dose consisting of 2g of azithromycin (Zithromax) achieved cure rates for syphilitic chancres comparable to penicillin G benzathine, and that individuals who were treated with azithromycin had cure rates at three, six, and nine months equivalent to those seen in patients treated with penicillin injections. What’s more, over 50% of the study population were HIV-positive and azithromycin was found to be as effective a treatment for syphilis in these patients as injections with penicillin. However, the investigators note that a strain of azithromycin-resistant syphilis has been found in HIV-positive individuals in the United States and Ireland. Many treatment guidelines recommend a single intramuscular injection with 2.4 million units (MU) of penicillin G benzathine for early syphilis. The main advantages of this treatment are low cost and a low risk of resistance. However, the injection can be painful, trained healthcare staff are required to administer them, many patients report an allergy to penicillin, and in low income settings, there is a risk that blood-borne organisms, including HIV, will be transmitted if injecting equipment is reused. It has a 68 hour half-life in tissue and has been shown to be an effective treatment for sexually transmitted infections including Chlamydia and gonorrhoea (although current UK treatment guidelines do not recommend its use for this infection).
500 mg PO once, then 250 mg once daily for 4 days 2 g extended release suspension PO once 500 mg IV as single dose for at least 2 days; follow with oral therapy with single dose of 500 mg to complete 7-10 days course of therapy Infection of pharynx, cervix, urethra, or rectum: Ceftriaxone 250 mg IM once plus azithromycin 1 g PO once (preferred) or alternatively doxycycline 100 mg PO q12hr for 7 days CDC STD guidelines: MMWR Recomm Rep. June 5, 20(RR3);1-137 Agitation Allergic reaction Anemia Anorexia Candidiasis Chest pain Conjunctivitis Constipation Dermatitis (fungal) Dizziness Eczema Edema Enteritis Facial edema Fatigue Gastritis Headache Hyperkinesia Hypotension Increased cough Insomnia Leukopenia Malaise Melena Mucositis Nervousness Oral candidiasis Pain Palpitations Pharyngitis Pleural effusion Pruritus Pseudomembranous colitis Rash Rhinitis Seizures Somnolence Urticaria Vertigo Anaphylaxis Angioedema Anorexia Bronchospasm Constipation Dermatologic reactions Dyspepsia Elevated liver enzymes Erythema multiforme Flatulence Oral candidiasis Pancreatitis Pseudomembranous colitis Pyloric stenosis, rare reports of tongue discoloration Stevens-Johnson syndrome Torsades de pointes Toxic epidermal necrolysis Vomiting/diarrhea, rarely resulting in dehydration Neutropenia Elevated bilirubin, AST, ALT, BUN, creatinine Alterations in potassium Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Use with caution in abnormal liver function, hepatitis, cholestatic jaundice, hepatic necrosis, and hepatic failure have been reported, some of which have resulted in death; discontinue azithromycin immediately if signs and symptoms of hepatitis occur Injection-site reactions can occur with IV route In treatment of gonorrhea or syphilis, perform susceptibility culture tests before initiating azithromycin therapy; may mask or delay symptoms of incubating gonorrhea or syphilis. Bacterial or fungal superinfection may result from prolonged use Prolonged QT interval: Cases of torsades de pointes have been reported during postmarketing surveillance; use with caution in patients with known QT prolongation, history of torsades de pointes, congenital long QT syndrome, bradyarrhythmias, or uncompensated heart failure; also use with caution if coadministering with drugs that prolong QT interval or proarrhythmic conditions (eg, hypokalemia, hypomagnesemia); elderly patients may be more susceptible to drug-associated effects on QT interval Pneumonia: PO azithromycin is safe and effective only for community-acquired pneumonia (CAP) due to C pneumoniae, H influenzae, M pneumoniae, or S pneumoniae Cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) reported; despite successful symptomatic treatment of allergic symptoms, when symptomatic therapy was discontinued, allergic symptoms recurred soon thereafter in some patients without further azithromycin exposure; if allergic reaction occurs, the drug should be discontinued and appropriate therapy instituted; physicians should be aware that allergic symptoms may reappear when symptomatic therapy discontinued Endocarditis prophylaxis: Indicated only for high-risk patients, per current AHA guidelines Use caution in renal impairment (Cr Cl Because of the low levels of azithromycin in breastmilk and use in infants in higher doses, it would not be expected to cause adverse effects in breastfed infants (Lact Med; https://nih.gov/newtoxnet/lactmed.htm) Binds to 50S ribosomal subunit of susceptible microorganisms and blocks dissociation of peptidyl t RNA from ribosomes, causing RNA-dependent protein synthesis to arrest; does not affect nucleic acid synthesis Concentrates in phagocytes and fibroblasts, as demonstrated by in vitro incubation techniques; in vivo studies suggest that concentration in phagocytes may contribute to drug distribution to inflamed tissues Y-site: Amikacin, aztreonam, cefotaxime, ceftazidime, ceftriaxone, cefuroxime, ciprofloxacin, clindamycin, droperidol, famotidine, fentanyl, furosemide, gentamicin, imipenem, cilastatin, ketorolac, levofloxacin, morphine, piperacillin-tazobactam, ondansetron(? ), potassium chloride, ticarcillin-clavulanate, tobramycin The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Eric,8 (eight) 250mg doses taken at the same time will be the same as a full single dose of 2g of Azithromycin. If not, please click on the green"Accept" button on this page. But please remember that the 8 capsules of 250mg will need to be taken one after the other in a row at the same time. A positive rating and adding a bonus will be warmly appreciated.. However, it is not recommended as a treatment for gonorrhea, because that dose is associated with gastrointestinal tract symptoms in 35% of patients and is expensive; furthermore, such a regimen produces sustained low levels of drug, a situation considered to be favorable for the induction of resistance in gonococci [85, 113, 114Reply to Family Physician's Post: Thank you. What would you recommend as a treatment for gonorrhea/chlymdia? I have not used this site before and want you to be paid for your information - do I need to ask new question for you to respond to this?
Jan 25, 2019. tinidazole, Tindamax, scored tabs, Adults 2g once daily for 2 days or. scored tabs, Adults gemifloxacin 320mg once + azithromycin 2g once. Azithromycin, as the dihydrate, is a white crystalline powder with a molecular formula of C 38 H 72 N 2 O 12 •2H 2 O and a molecular weight of 785.0. Zmax is a single-dose, extended-release formulation of microspheres for oral suspension containing azithromycin as azithromycin dihydrate and the following excipients glyceryl behenate, poloxamer 407, sucrose, sodium phosphate tribasic.