A 2018 meta-analysis of the comparative efficacy of 16 antidepressants found strong evidence of efficacy for all antidepressants except bupropion and vilazodone, both of which had few available clinical trials; A meta-analysis from 2009 found that bupropion is as effective as several other widely prescribed drugs, including fluoxetine and paroxetine, although trends favoring the efficacy of escitalopram, sertraline, and venlafaxine over bupropion have been observed. In depressed people who experience symptoms of sleepiness and fatigue, bupropion has been found to be more effective than selective serotonin reuptake inhibitors (SSRIs) in alleviating these symptoms. A typical bupropion treatment course lasts up to twelve weeks, with people halting the use of tobacco about ten days into the course. Bupropion increases the likelihood of quitting smoking by approximately 1.6 fold. Animal studies indicate that administration of bupropion at less than the recommended therapeutic dose may actually enhance the rewarding properties of nicotine, i.e., low doses augment nicotine self-administration and high doses attenuate it. In a double-blind study of children, while aggression and hyperactivity as rated by the children's teachers were significantly improved in comparison to placebo, parents and clinicians could not distinguish between the effects of bupropion and placebo. The 2007 guideline on the ADHD treatment from American Academy of Child and Adolescent Psychiatry notes that the evidence for bupropion is "far weaker" than for the FDA-approved treatments. Generic Name: bupropion (byoo PRO pee on)Brand Names: Aplenzin, Buproban, Forfivo XL, Wellbutrin SR, Wellbutrin XL, Zyban, Zyban Advantage Pack, Budeprion XL Medically reviewed by Sophia Entringer, Pharm D. Wellbutrin (bupropion) is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder. Wellbutrin may also be used for purposes not listed in this medication guide. You should not take Wellbutrin if you have seizures, an eating disorder, or if you have suddenly stopped using alcohol, seizure medications, or sedatives. If you take Wellbutrin for depression, do not also take Zyban to quit smoking. Do not use Wellbutrin if you have used an MAO inhibitor in the past 14 days. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Wellbutrin may cause seizures, especially in people with certain medical conditions or when using certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.
Mgkg−1 LD50, Maus, oral. Soweit möglich und gebräuchlich, werden SI- Einheiten verwendet. Wenn nicht anders vermerkt, gelten die angegebenen Daten bei Standardbedingungen. Bupropion bis 2000 lautete der INN Amfebutamon ist ein Arzneistoff, der zur Behandlung von. Response, usually defined as a ⩾50% symptom reduction, is typically. The search criteria were as follows 'bupropion' OR 'Wellbutrin' OR.