Memory reconsolidation impairment using the β-noradrenergic receptor blocker propranolol is a promising novel treatment avenue for patients suffering from pathogenic memories, such as post-traumatic stress disorder (PTSD). However, in order to better inform targeted treatment development, the effects of this compound on memory need to be better characterized via translational research. We examined the effects of systemic propranolol administration in mice undergoing a wide range of behavioral tests to determine more specifically which aspects of the memory consolidation and reconsolidation are impaired by propranolol. We found that propranolol (10 mg/kg) affected memory consolidation in non-aversive tasks (object recognition and object location) but not in moderately (Morris water maze (MWM) to highly (passive avoidance, conditioned taste aversion) aversive tasks. doi: 10.3389/fnbeh.2016.00049 © 2016 Villain, Benkahoul, Drougard, Lafragette, Muzotte, Pech, Bui, Brunet, Birmes and Roullet. Further, propranolol impaired memory reconsolidation in the most and in the least aversive tasks, but not in the moderately aversive task, suggesting its amnesic effect was not related to task aversion. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Moreover, in aquatic object recognition and location tasks in which animals were forced to behave (contrary to the classic versions of the tasks); propranolol did not impair memory reconsolidation. The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Taken together our results suggest that the memory impairment observed after propranolol administration may result from a modification of the emotional valence of the memory rather than a disruption of the contextual component of the memory trace. doi: 10.1016/j.psychres.20 Pub Med Abstract | Cross Ref Full Text | Google Scholar Villain H, Benkahoul A, Drougard A, Lafragette M, Muzotte E, Pech S, Bui E, Brunet A, Birmes P and Roullet P (2016) Effects of Propranolol, a β-noradrenergic Antagonist, on Memory Consolidation and Reconsolidation in Mice. No use, distribution or reproduction is permitted which does not comply with these terms. “The effect sizes obtained for pre-reactivation propranolol in our study compare well to those obtained with the best evidence-based treatment for PTSD, namely, cognitive-behavioral therapy, as well as those obtained with the most recommended pharmacological treatment for PTSD, namely, SSRIs,” researchers wrote in the study, according to a . “Should these results be replicated in further studies, propranolol blockade of reconsolidation [of traumatic memories] may become a new therapy for some patients with PTSD.” The double-blind trial randomized 60 adults with long-standing PTSD to propranolol, a nonadrenergic beta-receptor blocker, or placebo. Participants ingested their assigned agent 90 minutes before a brief memory reactivation session—in which they were asked to write and then read aloud a detailed first-person narrative of their traumatic memory—once a week for 6 weeks. MDMA Granted Breakthrough Therapy Designation for PTSD Participants completed the patient-rated PTSD Checklist-Specific (PCL-S) at each session before receiving their treatment. At the start and end of the trial, clinicians assessed patients using the Clinician-Administered PTSD Scale (CAPS). Although PCL-S and CAPS scores were similar for both groups at baseline and both groups had decreased scores at the posttreatment assessment, decreases in the propranolol group were significantly greater, compared with the placebo group, according to the study. Antioxidant Reduces PTSD Symptoms, Cravings reported mean CAPS scores of 52.0 for the propranolol group and 69.2 for the placebo group, and mean PCL-S scores of 38.4 with propranolol and 69.0 with placebo, at a 6-month follow-up.
It is known that, in animals, reconsolidation can be manipulated with propranolol to erase fearful memories, and a preliminary study has hinted. Jan 19, 2018. Our research demonstrated that one pill of propranolol 40 mg administered prior to or after memory reactivation effectively neutralized the.