The UK Prospective Diabetes Study, a large clinical trial performed in 1980-90s, provided evidence that metformin reduced the rate of adverse cardiovascular outcomes in overweight patients with type 2 diabetes relative to other antihyperglycemic agents. Treatment guidelines for major professional associations including the European Association for the Study of Diabetes, the European Society for Cardiology and the American Diabetes Association, now describe evidence for the cardiovascular benefits of metformin as equivocal. In 2017, the American College of Physicians's guidelines were updated to recognize metformin as the first-line treatment for type-2 diabetes. For example, a 2014 review found tentative evidence that people treated with sulfonylureas had a higher risk of severe low blood sugar events (RR 5.64), though their risk of non-fatal cardiovascular events was lower than the risk of those treated with metformin (RR 0.67). There was not enough data available at that time to determine the relative risk of death or of death from heart disease. study known as the Diabetes Prevention Program, participants were divided into groups and given either placebo, metformin, or lifestyle intervention and followed for an average of three years. Metformin treatment of people at a prediabetes stage of risk for type 2 diabetes may decrease their chances of developing the disease, although intensive physical exercise and dieting work significantly better for this purpose. The intensive program of lifestyle modifications included a 16-lesson training on dieting and exercise followed by monthly individualized sessions with the goals of decreasing weight by 7% and engaging in physical activity for at least 150 minutes per week. The incidence of diabetes was 58% lower in the lifestyle group and 31% lower in individuals given metformin. Among younger people with a higher body mass index, lifestyle modification was no more effective than metformin, and for older individuals with a lower body mass index, metformin was no better than placebo in preventing diabetes. Metformin is a relatively safe drug with no major side effects that would help with insulin resistance and weight loss. For those who are seriously overweight metformin can be a useful tool to get the process started, but experts recommend that it should be discontinued as soon as the BMI has come below 35. A study a couple of years ago found that regular exercise and a low GI/GL diet were more effective than metformin anyway and without the nasty side effects. There are natural supplements like Chromium that also acts as blood sugar regulator and works similarly to Metformin, and in a much safe manner. If you are looking for metformin, specifically for weight loss, we recommend chromium supplements instead, like Phen375 and Instant Knockout. If you are diabetic, we recommend The Big Diabetes lie program.
Also known as: Fortamet, Glucophage, Glucophage XR, Glumetza, Riomet The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care."Metformin was horrible for me. I was on it for over 6 months and had severe stomach problems/diarrhea the whole time. I had to finally tell my doctor ENOUGH and moved on to an injection.""Gave me very bad stomach issues, caused me to develop a heart problem, and I stayed in bed the entire year and a half that I was on it. Metformin is a horrible drug that should not be on the market at all. Made me very weak, tired, caused dehydration due to not being able to keep anything at all in my system. After taking it, I developed IBS and other issues aside from CHF.""This is the worst medicine I have ever taken. I would rather have high blood sugar than take this medicine. This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. " July 20, 2005 -- One of the many medications used to treat type 2 diabetes may stand out above the rest. Metformin used alone is still the best for lowering blood sugar and preventing complications of type 2 diabetes in people who are overweight or obese, according to a new review. Researchers analyzed 29 major trials of metformin (brand name Glucophage). "Our review of the literature suggests that metformin is a good first-line therapy for overweight or obese people with type 2 diabetes," researcher Antonio Saenz, MD, concludes. There are now more than a dozen blood sugar-lowering or insulin-sensitizing medications approved for the treatment of type 2 diabetes.
A review of metformin use during pregnancy compared to insulin alone found good short term safety for both the mother and baby but unclear long term safety. Several observational studies and randomized, controlled trials found metformin to be as effective and safe as insulin for the management of gestational diabetes. Find or Review a Drug;. Read user comments about the side effects, benefits, and effectiveness of metformin oral. Now on Metformin 1000mgX2 for 2 weeks. One day of diarrhea.