Patients treated with a drug widely prescribed for type 2 diabetes can live longer than people without the condition, a large-scale study involving over 180,000 people has shown. The findings indicate that a drug known asmetformin, used to control glucose levels in the body and already known to exhibit anticancer properties, could offer prognostic and prophylactic benefits to people without diabetes. Published in a leading diabetes journal, Diabetes, Obesity and Metabolism by scientists from Cardiff University, the study set out to compare the survival of diabetes patients prescribed with metformin with patients prescribed with another common diabetes drug called sulphonylurea. Importantly, the life expectancy of these cohorts was also compared against non-diabetics who were matched based on criteria that included age, gender, same general practice, smoking status and clinical status. "What we found was illuminating," said lead author Professor Craig Currie from Cardiff University's School of Medicine. "Patients treated with metformin had a small but statistically significant improvement in survival compared with the cohort of non-diabetics, whereas those treated with sulphonylureas had a consistently reduced survival compared with non-diabetic patients. This was true even without any clever statistical manipulation. Summary: Report on metformin and anti-aging medicine. To find out if the type 2 diabetes drug metformin will extend lifespan, researchers are conducting a $65 million clinical trial of metformin as an anti-aging drug. Here’s what both sides of the metformin debate have to say. [This article first appeared on the website Longevity ] A drug costing 5 cents could help us live longer, healthier lives. Used for decades to treat type 2 diabetes, metformin is showing promise as an anti-aging drug. Researchers are looking into whether metformin holds the key to living longer — and the latest research has been favorable. What we know today as metformin, has a long history.
The oral medicine metformin may be able to slow aging, increasing the number of healthy years a person can live and potentially expanding human lifespan to 120, according to the premise of a new study recently approved by the U. Food and Drug Administration (FDA) and set begin in the United States next winter. Previous research in worms has indicated that metformin may slow the aging process by mimicking the effects of a low-calorie diet. Metformin is the most widely prescribed diabetes drug in the world, with over 61 million prescriptions filled in 2012 in the U. And a study from Cardiff University found that people with diabetes who were taking the medicine lived longer than those without the condition who were not taking metformin. The drug’s anti-aging properties appear, at least in part, to be due to its effect of increasing the amount of oxygen that is released into cells. To further evaluate whether the medicine can lengthen lifespan and reduce disease in humans, researchers from various institutions in the United States are currently recruiting 3,000 people who are 70 to 80 years old and who have or are at risk of developing cancer, heart disease, or dementia. The trial, which is known as the Targeting Aging With Metformin (TAME) study, is expected to last from five to seven years. “If you target the aging process and slow down aging, then you slow down all the disease and pathology of aging as well,” notes study advisor and aging expert Gordon Lithgow, Ph D. “I have been doing research into aging for 25 years and the idea that we would be talking about a clinical trial in humans for an anti-aging drug would have been thought inconceivable. .pass_color_to_child_links a.u-margin-left--xs.u-margin-right--sm.u-padding-left--xs.u-padding-right--xs.u-relative.u-absolute.u-absolute--center.u-width--100.u-flex-inline.u-flex-align-self--center.u-flex-justify--between.u-serif-font-main--regular.js-wf-loaded .u-serif-font-main--regular.amp-page .u-serif-font-main--regular.u-border-radius--ellipse.u-hover-bg--black-transparent.u-hover-bg--black-transparent:hover. Content Header .feed_item_answer_user.js-wf-loaded .
Clinical lists 1989 clinical trials mentioning Metformin but only three clinical trials mentioning Metformin and longevity. All three of these are placebo. Aug 1, 2017. The Dark Side Of Metformin A "Longevity Wonder Drug" That Promises to Extend Life For A Nickel A Pop.