Дулоксетин (торговые названия Симбалта, Интрив) – это гетероциклический антидепрессант третьего поколения, относится к группе ингибиторов обратного захвата норэпинефрина и серотонина. Является сравнительно новым препаратом с очень низким седативным действием и не влияет на ВНС. Является самым безопасным гетероциклическим антидепрессантом. На основе Дулоксетина выпускается кроме одноименного препарата еще два — Симбалта и Yentreve (Интрив). Обнаружено, что в мозгу больных, страдающих эндогенными депрессиями, снижен уровень биогенных аминов, прежде всего серотонина и норэпинефрина. Дулоксетин повышает содержание этих медиаторов в синаптической щели посредством уменьшения обратного захвата. Важную роль в механизме антидепрессивного действия играют изменения постсинаптических рецепторов, которые развиваются при длительном применении препарата. Установлено, что примерно через 2-3 недели после начала приема лекарства возникает снижение чувствительности бета-адренорецепторов и серотониновых рецепторов (так называемая down-regulation). Ive been taking cymbalta for about 3-4 months now for dysthymia/ major depression and I'm ready to get off. i have 22 pills left I was wondering if i can get off by taking one every other day for a week, then every 2 days and so onor should i go down to 30 mg first and do that? I could consult a doctor but i feel like the doctor would take to long i want to get off ASAP.i was thinking 30 mg then every other day because when i started i started on 30 mg for a week then moved to 60 Hi Sunshine27. Best wishes, WCV DO NOT try to get off this med quickly. Even though you have been taking it for only two weeks your body could already be dependent on it. This med needs to be tapered off slowly or you can have serious long lasting side effects. You could experience many of the withdrawal symptoms or you could be one of the blessed ones who only have a few. I really worry about people who get off Cymbalta and other medications like it. Due to the extremely short half life of this drug skipping days merely causes you to go in and out of withdrawal. The symptoms vary; but I will tell you some of mine. Just make sure that you taper correctly or your road to recovery will be so much worse. I hope you all have realized that you need to taper slowly off these drugs. You can go down to 30mg for a month then down to 20mg for a month then try to go off or divide the dose in 1/2 so it is 10 mg for a month and get off from there. I have insomnia, diarrhea at times and constipation other times. My anxiety is through the roof and it’s hard for me to concentrate. The best way to do is is taper at 10% every 12-14 days. You may even need to get down to a 5 mg dose for a month before you can get off without alot of side effects. I’m having a hard time to get through this message; but I want to help you in any way that I can. If at any time you get withdrawal symptoms then get back on the previous dose or you will suffer. Just keep in mind that many people have a relapse of their symptoms when they stop taking their meds.
It is a thiophene derivative and a selective neurotransmitter reuptake inhibitor for serotonin, norepinephrine, and to a lesser degree dopamine. It belongs to a class of heterocyclic antidepressants known as a serotonin–norepinephrine reuptake inhibitors (SNRI). Duloxetine failed to receive US approval for stress urinary incontinence amid concerns over liver toxicity and suicidal events; however, it was approved for this indication in the UK, where it is recommended as an add-on medication in stress urinary incontinence instead of surgery. The main uses of duloxetine are in major depressive disorder, generalized anxiety disorder, urinary incontinence, neuropathic pain, chronic musculoskeletal pain, and fibromyalgia. Duloxetine was approved for the treatment of major depression in 2004. While duloxetine has demonstrated improvement in depression-related symptoms compared to placebo, comparisons of duloxetine to other antidepressant medications have been less successful. A 2012 Cochrane Review did not find greater efficacy of duloxetine compared to SSRIs and newer antidepressants. Additionally, the review found evidence that duloxetine has increased side effects and reduced tolerability compared to other antidepressants. Fluoxetine is frequently used to treat major depressive disorder, obsessive–compulsive disorder (OCD), post-traumatic stress disorder (PTSD), bulimia nervosa, panic disorder, premenstrual dysphoric disorder, and trichotillomania. The effectiveness of fluoxetine and other antidepressants in the treatment of mild-to-moderate depression is controversial. A review of the comparative efficacy of 21 antidepressant drugs found that fluoxetine was among the least effective for treatment of depression. A 2009 meta-analysis by Fournier which evaluated patient-level data from six trials of the SSRI paroxetine and the non-SSRI antidepressant imipramine has been further cited as evidence that antidepressants exhibit minimal efficacy in mild to moderate depression. A 2012 meta-analysis using individual patient level-data of fluoxetine for the treatment of depression concluded statistically and clinically significant benefit was seen irrespective of baseline depression severity, and no significant effect was found on baseline severity on observed efficacy. A 2009 systematic review by the National Institute of Care and Clinical Excellence (NICE) (which considered the Kirsch, but not the later meta-analyses) concluded strong evidence existed for the efficacy of SSRIs in the treatment of moderate and severe depression, with some evidence for their efficacy in the treatment of mild depression. Both the NICE and the Fournier analyses concluded that greater evidence is seen for the efficacy of antidepressants in the treatment of chronic mild depression (dysthymia) than in recent-onset mild depression.
Looking for online definition of duloxetine in the Medical Dictionary? duloxetine explanation. Half-life 12 hr. Time/action. life-threatening seizures. Duloxetine does not inhibit monoamine oxidase MAO. Duloxetine undergoes extensive metabolism, but the major circulating metabolites have not been shown to contribute significantly to the pharmacologic activity of duloxetine. Pharmacokinetics Duloxetine has an elimination half-life of about 12 hours range 8 to 17 hours and its